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Analysis of institutional authors

Hartley, WcAuthorSchiel, FAuthorMelchiorre, PCorresponding Author

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June 2, 2022
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Article

Lewis Base-Catalysed Enantioselective Radical Conjugate Addition for the Synthesis of Enantioenriched Pyrrolidinones

Publicated to: Angewandte Chemie (International Ed. Print). 61 (26): e202204735-- - 2022-06-27 61(26), DOI: 10.1002/anie.202204735

Authors:

Hartley, WC; Schiel, F; Ermini, E; Melchiorre, P
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Affiliations

Barcelona Inst Sci & Technol, ICIQ Inst Chem Res Catalonia, Ave Paisos Catalans 16, Tarragona 43007, Spain - Author
ICREA, Passeig Lluis Companys 23, Barcelona 08010, Spain - Author
Univ Rovira & Virgili, Tarragona 43007, Spain - Author
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Abstract

We report a catalytic asymmetric protocol for the preparation of chiral pyrrolidinones proceeding via a radical pathway. The chemistry exploits the combination of photoredox catalysis and Lewis base catalysis to realise the first example of asymmetric radical conjugate addition to alpha,beta-unsaturated anhydrides and esters. The reaction is initiated by photoredox activation of N-arylglycines to generate, upon decarboxylation, alpha-amino radicals. These radicals are then intercepted stereoselectively by alpha,beta-unsaturated acyl ammonium intermediates, whose formation is mastered by a chiral isothiourea organocatalyst. Cyclisation leads to catalyst turnover and formation of enantioenriched pyrrolidinones. The utility of the protocol was demonstrated with application to the synthesis of biologically-active gamma-amino butyric acids.
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Keywords

enantioselectivitylewis base catalysisorganocatalysisphotochemistryAcidAcylammonium saltsAlpha-amino radicalsAsymmetric organocatalysisBeta-hydroxylationDrivenEfficientPhotoredox catalysisRadical reactions

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Angewandte Chemie (International Ed. Print) due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 13/178, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Multidisciplinary. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.42. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-12-29, the following number of citations:

  • WoS: 21
  • Google Scholar: 18
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-29:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 36.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 36 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 23.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 40 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/2072/530004
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Hartley, Will) and Last Author (Melchiorre, Paolo).

the author responsible for correspondence tasks has been Melchiorre, Paolo.

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Awards linked to the item

Financial support was provided by Agencia Estatal de Investigacion (PID2019-106278GB-I00 and CEX2019-000925-S). W.C. Hartley thanks the EU for a Horizon 2020 Marie Skodowska-Curie Fellowship (H2020-MSCA-IF-2020 101031533). We thank Prof. A.D. Smith for gracious donation of a sample of catalyst C.
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