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Analysis of institutional authors

Gadekar, Santosh CAuthorVelasco-Rubio, álvaroAuthorRodrigalvarez, JesusAuthorMartin, RubenCorresponding Author

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October 22, 2025
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Article

Regiodivergent Deuteration of Pyridine-Based Heterocycles

Publicated to: Organic Letters. 27 (41): 11428-11433 - 2025-10-06 27(41), DOI: 10.1021/acs.orglett.5c02961

Authors: Du, Wei; Gadekar, Santosh C; Velasco-Rubio, Alvaro; Rodrigalvarez, Jesus; Martin, Ruben

Affiliations

Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Ave Paisos Catalans 16, Tarragona 43007, Spain - Author
ICREA, Passeig Lluis Companys 23, Barcelona 08010, Spain - Author
Univ Rovira & Virgili, Dept Quim Organ, Tarragona 43007, Spain - Author
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Abstract

Herein, we describe a regiodivergent deuteration of pyridotriazoles under mild conditions. Site-selective deuteration can be tuned, controlled, and switched by a subtle interplay of the base and solvent utilized. Given the ease at which pyridotriazoles can be converted into a variety of pyridine congeners, this protocol might offer a new gateway to access a variety of deuterium-labeled pyridine-containing heterocycles in a site-selective, yet predictable, manner.

Keywords

DeuteriumDiscoveryDrugFunctionalizationHydrogen isotope-exchangeReactivityTransannulationTritiation

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Organic Letters due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 4/57, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Organic. Notably, the journal is positioned above the 90th percentile.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-06:

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.
  • The number of mentions on the social network X (formerly Twitter): 6 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Du, Wei) and Last Author (Martin Romo, Rubén).

the author responsible for correspondence tasks has been Martin Romo, Rubén.

Awards linked to the item

We thank ICIQ, FEDER/MCI PID2021-123801NB-I00, PID2019-110008GB-I00, PID2024-160739NB-I00/MICIU AIE/10.13039/501100011033/FEDER, UE and MCI/AIE (Severo Ochoa Excellence Accreditation 2002-2023, CEX2019-000925-S). W.D. thanks China Scholarship Council (CSC) for a predoctoral fellowship. We thank Prof. E. Hevia and Dr. D. S. Roa (Department fur Chemie, Biochemie and Pharmazie, Univesitat Bern) for insightful discussions on DOSY experiments. S.C.G. thanks the European Union's Harizone 2020 and innovation program under the Marie Sk & lstrok;odowska-Curie grand agreement (894998).