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Analysis of institutional authors

Puggioli, AlessioAuthorJiang, LiyinAuthorNannini, Leonardo JAuthorDe La Vega-Hernandez, KarenAuthorSuero, Marcos GCorresponding Author

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April 12, 2025
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Article

Late-Stage Photoredox-Catalyzed Aryl C-H Bond Diazomethylation with Atomic Carbon Reagents

Publicated to: Journal Of The American Chemical Society. 147 (13): 11309-11317 - 2025-03-21 147(13), DOI: 10.1021/jacs.5c00045

Authors:

Puggioli, A; Jiang, LY; Herraiz, AG; Nannini, LJ; de la Vega-Hernández, K; Rey-Blanco, A; Diéguez-Vázquez, A; Cañellas, S; Suero, MG
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Affiliations

Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ CERCA, Tarragona 43007, Spain - Author
ICREA, Barcelona 08010, Spain - Author
Janssen Cilag SA, Chem Capabil Analyt & Purificat, Global Discovery Chem, E-45007 Toledo, Spain - Author
Univ Rovira i Virgili, Dept Quim Analit & Quim Organ, Tarragona 43007, Spain - Author
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Abstract

Herein, we present a novel class of diazo compounds as atomic carbon reagents substituted with two orthogonal redox-active leaving groups that were exploited in the late-stage construction of chiral centers with aryl C-H bonds from aromatic feedstocks and drug molecules. Key to the strategy was the use of photoredox catalysis to enable an initial C-H diazomethylation reaction able to generate diazomethyl-substituted redox-active esters. Subsequent construction of chiral centers with readily available starting materials proceeded using a broad range of well-known diazo and redox-active ester functionalizations. Moreover, the applicability of our novel atomic carbon reagent was tested in the automated parallel synthesis of a library of Fenofibrate derivatives.
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Keywords

EsterInsertionPhotolysis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal JOURNAL OF THE AMERICAN CHEMICAL SOCIETY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 17/239, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Multidisciplinary. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-04:

  • WoS: 3
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 14.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 14 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 17.
  • The number of mentions on the social network X (formerly Twitter): 33 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/2072/482477
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Puggioli, Alessio) and Last Author (García Suero, Marcos).

the author responsible for correspondence tasks has been García Suero, Marcos.

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Awards linked to the item

European Research Council (ERC-CoG 2019, 865554), Agencia Estatal de Investigacion (AEI, 10.13039/501100011033) of the Ministerio de Ciencia, Innovacion y Universidades (PID2022-140286NB-I00, Severo Ochoa Excellence Accreditation 2020-2023 CEX2019-000925-S), ICIQ Foundation and the CERCA Programme (Generalitat de Catalunya) are gratefully acknowledged for financial support. We thank the European Union for Marie Sk & lstrok;odowska-Curie Individual Fellowships (794815 to L.J. and 101110735 to K.V.H.), as well as AEI for a FPI-SO predoctoral fellowship (PRE2021-097799 to A.P.).
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