{rfName}
Sy

Indexed in

License and Use

Icono OpenAccess

Citations

31

Altmetrics

Analysis of institutional authors

Lamparelli, DhAuthorPericas, MaAuthorKleij, AwCorresponding Author

Share

May 2, 2023
Publications
>
Article

Synthesis of Biorenewable Terpene Monomers Using Enzymatic Epoxidation under Heterogeneous Batch and Continuous Flow Conditions

Publicated to: Acs Sustainable Chemistry & Engineering. 11 (12): 4885-4893 - 2023-03-27 11(12), DOI: 10.1021/acssuschemeng.3c00370

Authors:

Brandolese, A; Lamparelli, DH; Pericas, MA; Kleij, AW
[+]

Affiliations

Barcelona Inst Sci & Technol BIST, Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain - Author
Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain - Author
Univ Ferrara, Dept Environm & Prevent Sci, Via L Borsari 46, I-44121 Ferrara, Italy - Author
Univ Rovira & Virgili, Tarragona 43007, Spain - Author
See more

Abstract

A commercially available Lipase B from Candida antarctica immobilized onto a macroporous support (Novozym 435) has been employed in the presence of H2O2 as a benign oxidant for the epoxidation of various biorenewable terpenes. This epoxidation protocol was explored under both heterogeneous batch and continuous flow conditions. The catalyst recyclability was also investigated demonstrating good activity throughout 10 cycles under batch conditions, while the same catalyst system could also be productively used under continuous flow operation for more than 30 h. This practical and relatively safe sustainable flow epoxidation of di-and trisubstituted alkenes by H2O2 allows for the production of gram quantities of a range of terpene epoxides. As a proof of principle, the same protocol can also be applied to the epoxidation of biobased polymers as a means to post-functionalize these macromolecules and equip them with cross-linkable epoxy groups.
[+]

Keywords

AccessCatalyzed synthesisChemicalsChemoenzymatic epoxidationContinuous flowCopolymerizationEnzymatic catalysisEnzymatic-synthesisEpoxidationFlow biocatalysisLinear terpenesLipase-mediated epoxidationPeroxycarboxylic acidsPolymersTerpenes

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Acs Sustainable Chemistry & Engineering due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 21/170, thus managing to position itself as a Q1 (Primer Cuartil), in the category Engineering, Chemical.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.14. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-12-30, the following number of citations:

  • WoS: 10
[+]

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-30:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 23.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 23 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 11.
  • The number of mentions on the social network X (formerly Twitter): 13 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/2072/532933
[+]

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Italy.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Brandolese, A) and Last Author (Kleij, Arjan).

the authors responsible for correspondence tasks have been Brandolese, A and Kleij, Arjan.

[+]

Awards linked to the item

The authors thank the CERCA program/Generalitat de Catalunya, ICREA, MICINN (PID2020-112684GB-100, PID2019-109236RB-I00, the Severo Ochoa Excellence Accreditation 2020-2023 CEX2019-000925-S) and the ERDF (European Regional Development Fund) through the POCTEFA Interreg program (EFA308/19, TRIPyr) for support. D.H.L. acknowledges MICINN for a postdoctoral fellowship (PDC2021-120952-I00, MacroLemon). The authors further thank Isobionics for a kind donation of B-elemene and Novozyme for the generous donation of Novozym 435.
[+]

Related Items